Finding cures for children's genetic diseases

Publications

Telomere Length Regulation Group

 

Recent Publications

Dagg, R. A., Pickett, H. A., Neumann, A. A., Napier, C. E.,  Henson, J. D., Teber, E. T., Arthur J. W., Reynolds, C. P., Murray, J., Haber, M., Sobinoff A. P., Lau, L. M. S., Reddel, R. R., 2017. Extensive proliferation of human cancer cells with ever-shorter telomeres. Cell Reports, 19, 2544-2556. PMID: 28636942.
 
Helbig, S., Wockner, L., Bouendeu, A., Hille-Betz, U., McCue, K., French, J. D., Edwards, S. L., Pickett, H. A., Reddel, R. R., Chenevix-Trench, G., Dork, T., Beesley, J., 2017. Functional dissection of breast cancer risk-associated TERT promoter variants. Oncotarget, doi: 10.18632/oncotarget.18226. PMID: 28615534.
 
Hayward, N. K., Wilmott, J. S., Waddell, N., Johansson, P. A., Field, M. A., Nones, K., Patch, A., Kakavand, H., Alexandrov, L. B., Burke, H., Jakrot, V., Kazakoff, S., Holmes, O., Leonard, C., Sabarinathan, R., Mularoni, L., Wood, S., Xu, Q., Waddell, N., Tembe, V., Pupo, G. M., De Paoli-Iseppi, R., Vilain, R. E., Shang, P., Lau, L. M. S., Dagg, R. A., Schramm, S., Pritchard, A., Dutton-Regester, K., Newell, F., Fitzgerald, A., Shang, C. A., Grimmond, S. M., Pickett, H. A., Yang, J. Y., Stretch, J. R., Behren, A., Kefford, R. F., Hersey, P., Long, G. V., Cebon, J., Shackleton, M., Spillane, A. J., Saw, R. P. M., Bigas, N. L., Pearson, J. V., Thompson, J. F., Scolyer, R. A., Mann, G. J., 2017. Whole-genome landscapes of major melanoma subtypes. Nature, 545, 175-180. PMID: 28467829.
 
Scarpa, A., Chang, D. K., Nones, K., Corbo, V., Patch, A., Bailey, P., Lawlor, R. T., Johns, A. L., Miller, D. K., Mafficini, A., Rusev, B., Scardoni, M., Antonello, D., Barbi, S., Sikora, K. O., Cingarlini, S., Vicentini, C., McKay, S., Quinn, M. C., Bruxner, T. J. C., Christ, A. N., Harliwong, I., Idrisoglu, S., McLean, S., Nourse, C., Nourbakhsh, E., Wilson, P. J., Anderson, M. J., Fink, J. L., Newell, F., Waddell, N., Holmes, O., Kazakoff, S. H., Leonard, C., Wood, S., Xu, Q., Nagaraj, S. H., Amato, E., Dalai, I., Bersani, S., Cataldo, I., Dei Tos, A. P., Capelli, P., Davi, M. V., Landoni, L., Malpaga, A., Miotto, M., Whitehall, V., Leggett, B., Harris, J. L., Harris, J., Jones, M. D., Humphris, J., Chantrill, L. A., Chin, V., Nagrial, A. M., Pajic, M., Scarlett, C. J., Pinho, A., Rooman, I., Toon, C., Wu, J., Pinese, M., Cowley, M., Barbour, A., Mawson, A., Humphrey, E. S., Colvin, E. K., Chou, A., Lovell, J. A., Jamieson, N. B., Duthie, F., Gingras, M. C., Fisher, W. E., Dagg, R. A., Lau, L. M., Lee, M., Pickett, H. A., Reddel, R. R., Samra, J. S., Kench, J. G., Merrett, N. D., Epari, K., Nguyen, N. Q., Zeps, N., Falconi, M., Simbolo, M., Butturini, G., Van Buren, G., Partelli, S., Fassan, M., Australian Pancreatic Cancer Genome Initiative, Khanna, K. K., Gill, A. J., Wheeler, D. A., Gibbs, R. A., Musgrove, E. A., Bassi, C., Tortora, G., Pederzoli, P., Pearson, J. V., Waddell, N., Biankin, A. V., Grimmond, S. M., 2017. Whole-genome landscape of pancreatic neuroendocrine tumours. Nature 543, 65-71. PMID: 28199314.
 
Lee, M., Napier, C. E., Yang, S. F., Arthur, J. W., Reddel, R. R., Pickett, H. A., 2017. Comparative analysis of whole genome sequencing-based telomere length measurement techniques. Methods 114, 4-15. PMID: 27565742.
 
Law, E., Girgis, A., Sylvie L., Levesque, J., Pickett, H. A., 2016. Telomeres and stress: Promising avenues for research in psycho-oncology. Asia Pac. J. Oncol. Nurs. 3, 137-147. PMID: 27981152.
 
O’Brien, R., Tran, S. L., Maritz, M., Liu, B., Kong, C. F., Purgato, S., Yang, C., Murray, J., Russell, A. J., Flemming, C. L., von Jonquieres, G., Pickett, H. A., London, W. B., Haber, M., Gunaratne, P. H., Norris, M. D., Perrini, G., Fletcher, J. I., MacKenzie, K. L., 2016. MYC-driven neuroblastomas are addicted to a telomerase-independent function of dyskerin. Cancer Res. 76, 3604-3617. PMID: 27197171.
 
Pickett, H. A., Reddel, R. R., 2015. Molecular mechanisms of alternative lengthening of telomeres activity and derepression. Nat. Struct. Mol. Biol. 22, 875-880. PMID: 26581522.
 
Udugama, M., Chang, F. T. M., Chan, F. L., Tang, M., Pickett, H. A., McGhie, J. D. R., Mayne, L., Collas, P., Mann, J. R., Wong, L. H., 2015. Histone variant H3.3 provides the heterochromatic H3 lysine 9 trimethylation mark at telomeres. Nucleic Acids Res. 43, 10227-10237. PMID: 26304540.
 
Killedar, A., Stutz, M. D., Sobinoff, A. P., Tomlinson, C. G., Bryan, T. M., Beesley, J., Chenevix-Trench, G., Reddel, R. R., Pickett, H. A., 2015. A common risk-associated allele in the hTERT locus encodes a dominant negative inhibitor of telomerase. PLOS Genet. 11 (6):e1005286. PMID: 26053551.

Guo, Y., Kartawinata, M., Li, J., Pickett, H. A., Teo, J., Kilo, T., Barbaro, P. M., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R. R., Christodoulou, J., Xu, X., Hakonarson, H., Bryan, T. M., 2014. Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood 2014-08-596445. PMID: 25205116.
 
Conomos, D., Reddel, R. R., Pickett, H. A., 2014. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nat. Struct. Mol. Biol. 21, 760-770. PMID:25150861.

Bull, C. F., Mayrhofer, G., O’Callaghan, N. J., Au, A. Y., Pickett, H. A., Kah Mun Low, G., Zeegers, D., Hande, M. P., Fenech, M. F., 2013. Folate deficiency induces dysfunctional long and short telomeres; both states are associated with hypomethylation and DNA damage in human WIL2-NS cells. Cancer Prev. Res. 7, 128-138. PMID: 24253316.
 
Lee, M., Hills, M., Conomos, D., Stutz, M. D., Dagg, R. A., Lau, L. M. S., Reddel, R. R., Pickett, H. A., 2013. Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Res. Accepted 22/10/13. PMID: 24225324.
 
Kojima, Y., Kaufman-Francis, K., Studdert, J. B., Steiner, K. A., Power, M. D., Loebel, D. A. F., Jones, V., Hor, A., de Alencastro, G., Logan, G., Teber, E. T., Tam, O. H., Stutz, M. D., Alexander, I. E., Pickett, H. A., Tam, P. P. L., 2013. The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak. Cell Stem Cell 14, 107-120. PMID: 24139757.
 
Bojesen, S. E., Pooley, K. A., Johnatty, S. E., Beesley, J., Michailidou, K., Tyrer, J. P., Edwards, S. L., Pickett, H. A., Shen, H. C., Smart, C. E., Hillman, K. M., Mai, P. L., Lawrenson, K., Stutz, M. D., Yu, L., Karevan, R., Woods, N., Johnston, R. L., French, J. D., Chen, X., Weischer, M., Nielsen, S. F., Maranian, M.J., Ghoussaini, M., Ahmed, S., et al., 2013. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat. Genet. 45, 371-384. PMID: 23535731.
 
Conomos, D., Pickett, H. A., Reddel, R. R., 2013. Alternative lengthening of telomeres: remodeling the telomere architecture. Front. Oncol. 3:27. doi: 10.3389/fonc.2013.00027. PMID: 23429284.
 
Neumann, A. A., Watson, C. M., Noble, J. R., Pickett, H. A., Tam, P. T., Reddel, R. R., 2013. Alternative lengthening of telomeres in normal mammalian somatic cells. Genes Dev. 27, 18-23. PMID: 23307865.
 
 

Key Publications

Conomos, D., Reddel, R. R., Pickett, H. A., 2014. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nat. Struct. Mol. Biol. 21, 760-770. PMID: 25150861.
 
Lee, M., Hills, M., Conomos, D., Stutz, M. D., Dagg, R. A., Lau, L. M. S., Reddel, R. R., Pickett, H. A., 2014. Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Res. 42, 1733-1746. PMID: 24225324
 
Conomos, D., Pickett, H. A., Reddel, R. R., 2013. Alternative lengthening of telomeres: remodeling the telomere architecture. Front. Oncol. 3:27. doi: 10.3389/fonc.2013.00027. PMID: 23429284.
 
Conomos, D., Stutz, M. D., Hills, M., Neumann, A. A., Bryan, T. M., Reddel, R. R., Pickett, H. A., 2012. Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. J. Cell Biol. 199, 893-906. PMID: 23229897.
 
Pickett, H. A., Henson, J. D., Au, A. Y. M., Neumann, A. A., Reddel, R. R., 2011. Normal mammalian cells negatively regulate telomere length by telomere trimming. Hum. Mol. Gen. 20, 4684-4692. PMID: 21903669.
 
Pickett, H. A., Cesare, A. J., Johnston, R. L., Neumann, A. A., Reddel, R. R., 2009. Control of telomere length by a trimming mechanism that involves generation of t-circles. EMBO J. 28, 799-809. PMID: 19214183.
 
Varley, H., Pickett, H. A., Foxon, J. L., Reddel, R. R., Royle, N. J., 2002. Molecular characterisation of inter-telomere and intra-telomere mutations in human ALT cells. Nat. Genet. 30, 301-305. PMID: 11919561