Finding cures for children's genetic diseases

Anai Gonzalez Cordero - Publications

Ovando-Roche P., West EL, Branch M.J, Sampson RD, Fernando M, Munro P, Georgiadis A, Rizzi M, Kloc M, Naeem A, Ribeiro J, Smith AJ, Gonzalez-Cordero A and Ali RR. 2018. Use of bioreactors for culturing human retinal organoids improves photoreceptor yields. Stem Cell Research and Therapeutics, 9:156.
Gonzalez-Cordero A, Goh D, Kruczek K, Naeem A, Fernando M, kleine Holthaus SM, Takaaki M, Blackford SJI, Kloc M, Agundez L, Sampson RD, Borooah S, Ovando-Roche P, Mehat MS, West EL, Smith AJ, Pearson RA, Ali RR. 2018. Assessment of AAV vector tropisms for mouse and human pluripotent stem cell-derived RPE and photoreceptor cells. Human Gene Therapy. 29:10
Waldron PVW, Marco F, Kruczek K, Ribeiro J, Graca AB, Hippert C, Aghaizu ND, Kalargyrou A, Barber AC, Grimaldi G, Duran Y, Blackford SJI, Kloc M, Goh D, Aldunate EZ, Sampson RD, Bainbridge JWB, Smith AJ, Gonzalez-Cordero A, Sowden JC, Ali RR,and Pearson RA. 2018. Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner. Stem Cell Reports; 10(2):406-421.
Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, Goh D, et al. 2017. Recapitulation of Human Retinal Development From Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors. Stem Cell Reports, 9 (3): 820–37.
Kruczek K, Gonzalez Cordero A, Goh D, Naeem A, Jonikas M, Blackford SJI, Kloc M, et al. 2017. Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors Into a Mouse Model of End-Stage Retinal Degeneration. Stem Cell Reports; 8 (6): 1659–74.
Welby E, Lakowski J, Di Foggia V, Budinger D, Gonzalez-Cordero A, Lun ATL, Epstein M, Patel A, Cuevas E, Kruczek K, Naeem A, Minneci F, Hubank M, Jones DT, Marioni JC, Ali RR, Sowden JC. 2017. lsolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-derived Cone Photoreceptor Cells. Stem Cell Reports. 12;9(6):1898-1915.
Fanelli G, Gonzalez Cordero A, Gardner PJ, Peng Q, Fernando M, Kloc M, Farrar CA, et al. 2017. Human Stem Cell-Derived Retinal Epithelial Cells Activate Complement via Collectin 11 in Response to Stress. Scientific Reports 7 (1).
Aghaizu ND, Kruczek K, Gonzalez-Cordero A, Ali RR, Pearson RA. 2017. Pluripotent stem cells and their utility in treating photoreceptor degenerations. Prog Brain Res.;231:191-223.
Pearson RA, Gonzalez-Cordero A, West EL, Ribeiro J, Aghaizu ND, Goh D, Sampson RD, Georgiadis A, Waldron PV, Duran Y, Naeem A, Kloc M, Cristante E, Kruczec K, Warre-Cornish K, Sowden JC, Smith AJ and Ali RR. 2016. Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors. Nature Communications 7,13029.
Georgiadis, A, Duran Y,  Ribeiro J,  Abelleira-Hervas L, Robbie SJ,  Sünkel-Laing B,  Fourali S, Gonzalez-Cordero A, Cristante E,  Michaelides M, Bainbridge JWB , Smith AJ  and Ali RR. 2016. Development of an Optimized AAV2/5 Gene Therapy Vector for Leber Congenital Amaurosis Owing to Defects in RPE65. Gene Therapy 23 (12).
Chu CJ, Gardner PJ, Liyanage SE, Gonzalez-Cordero A, kleine Holthaus SM, Copland DA, Luhmann UFO, Smith AJ, Ali RR, and Dick AD. 2016.  Multimodal analysis of ocular inflammation using endotoxin-induced uveitis Dis Model Mech., 1;9(4):473-81.
Jayakody SA, Gonzalez-Cordero A, Ali RR, & Pearson RA. 2015. Cellular strategies for retinal repair by photoreceptor replacement. Progress in Retinal and Eye Research, 1–36.
Lakowski J, Gonzalez-Cordero A, West EL, et al. 2015. Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell-Derived Self-Forming Retina. Stem Cells, 33(8), 2469–2482.
Geach TJ, Faas L, Devader C, Gonzalez-Cordero A, Tabler JM, Brunsdon H, Isaacs HV and Dale L. 2014. An essential role for LPA signalling in telencephalon development, Development, 141: 940–949.
Gonzalez-Cordero A, West EL, Pearson RA, Duran Y, Carvalho LS, Chu CJ, Naeem A, Blackford SJI, Georgiadis A, Lakowski J, Hubank M, Smith AJ, Bainbridge JWB, Sowden JC, Ali RR. 2013. ‘Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nature Biotechnology, 31: 741–747.

Gonzalez-Cordero A, West EL, Hippert C, Osakada F, Martinez-Barbera JP, Pearson RA, Sowden JC, Takahashi M, Ali RR. 2012b. Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem cells 30: 1424–1435.

West EL, Pearson RA, Duran Y, Gonzalez-Cordero A, Maclaren RE, Smith AJ, Sowden JC, Ali RR. 2012a. Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival. Cell Transplantation, 21: 871–887
Lakowski J, Han YT, Pearson RA, Gonzalez-Cordero A, West EL, Gualdoni S, Barber AC, Hubank M, Ali RR, Sowden JC. 2011. Effective Transplantation of Photoreceptor Precursor Cells Selected Via Cell Surface Antigen Expression, Stem cells 29: 1391–1404.