Finding cures for children's genetic diseases


Synapse Proteomics Group

Recent Publications:

1.      Parker BL, Thaysen-Andersen M, Solis N, Scott NE, Larsen MR, Graham ME, Packer NH, Cordwell SJ (2013) Site-specific glycan-peptide analysis for determination of N-glycoproteome heterogeneity. J. Proteome Res. 12:5791-800. PMID: 24090084
2.      Bolderson E, Savage KI, Mahen R, Pisupati V, Graham ME, Richard DJ, Robinson PJ, Venkitaraman AR and Khanna KK (2012) Kruppel-associated Box (KRAB)-associated Co-repressor (KAP-1) Ser-473 Phosphorylation Regulates Heterochromatin Protein 1β (HP1-β) Mobilization and DNA Repair in Heterochromatin. J. Biol. Chem. 287:28122-31. PMID: 22715096
3.      Palmisano G, Parker BL, Engholm-Keller K, Lendal SE, Kulej K, Schulz M, Schwämmle V, Graham ME, Saxtorph H, Cordwell SJ, Larsen MR (2012) A novel method for the simultaneous enrichment, identification, and quantification of phosphopeptides and sialylated glycopeptides applied to a temporal profile of mouse brain development. Mol. Cell. Proteomics, 11:1191-202.
PMID: 22843994
4.      Graham ME, Stone RS, Robinson PJ, Payne RJ (2012) Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked β-N-acetylglucosaminyl-6-phosphate modification. Org. Biomol. Chem., 10:2545-51. PMID: 22361808
5.      Quan A, Xue J, Wielens J, Smillie KJ, Anggono V, Parker MW, Cousin MA, Graham ME, Robinson PJ (2012) Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proc. Natl Acad. Sci. USA, 109:3760-5. PMID: 22355135
6.      Xue J, Graham ME, Novelle AE, Sue N, Gray N, McNiven MA, Smillie KJ, Cousin MA, Robinson PJ (2011) Calcineurin selectively docks with the dynamin Ixb splice variant to regulate activity-dependent bulk endocytosis. J. Biol. Chem., 286:30295-303. PMID: 21730063
7.      Graham ME, Thaysen-Andersen M, Bache N, Craft GE, Larsen MR, Packer NH, Robinson PJ (2011) A novel post-translational modification in nerve terminals: O-linked N-acetylglucosamine phosphorylation. J. Proteome Res., 10:2725-33. PMID: 21500857
8.      Chircop M, Sarcevic B, Larsen MR, Malladi CS, Chau N, Zavortink M, Smith CM, Quan A, Anggono V, Hains PG, Graham ME, Robinson PJ (2011) Phosphorylation of dynamin II at serine-764 is associated with cytokinesis. Biochim. Biophys. Acta, 1813:1689-99.
PMID: 21195118
9.      Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF (2011) Autophosphorylation and ATM activation: additional sites add to the complexity. J. Biol. Chem., 286:9107-19. PMID: 21149446
10.  Chan LS, Hansra G, Robinson PJ, Graham ME (2010) Differential phosphorylation of dynamin I isoforms in subcellular compartments demonstrates the hidden complexity of phosphoproteomes. J. Proteome Res., 9:4028-37. PMID: 20560669

Key Publications:

1.      Graham ME, Anggono VA, Bache N, Larsen MR, Craft GE and Robinson PJ (2007) The in vivo phosphorylation sites of rat brain dynamin I. J. Biol. Chem. 282:14695-707. PMID: 16648848
2.      Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ and Reddel RR (2007) Protein composition of catalytically active human telomerase from immortal cells. Science 315:1850-1853. PMID: 17395830
3.      Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ and Lavin, M. F. (2006) Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 25:3504-14. PMID: 16858402
4.      Bevilaqua LR, Graham ME, Dunkley PR, von Nagy-Felsobuki EI and Dickson PW. (2001) Phosphorylation of Ser19 alters the conformation of tyrosine hydroxylase to increase the rate of phosphorylation of Ser40. J. Biol. Chem. 276:40411-40416. PMID: 11502746