Finding cures for children's genetic diseases



Genome Integrity Group

Recent Publications

Hayashi MT, Cesare AJ, Rivera T and Karlseder J. (2015) Cell death during crisis is mediated by mitotic telomere deprotection. Nature. 522, 492-496

Cesare AJ, Heaphy CM and O’Sullivan RJ (2015). Visualization of telomere integrity and function in vitro and in vivo using immunofluorescence techniques. Current Protocols in Cytometry. 73:12.40.1-12.40.31. doi: 10.1002/0471142956.cy1240s73.  

Cesare AJ (2014). Mitosis, double strand break repair and telomeres: A view from the end: How telomeres and the DNA damage response cooperate during mitosis to maintain genome stability. Bioessays. PMID 25171524

Cesare AJ, Hayashi MT, Crabbe L, and Karlseder J (2013). The telomere deprotection response is functionally distinct from the genomic DNA damge response. Mol Cell. 51, 141-155. PMID: 23850488.

Crabbe L, Cesare AJ, Kasubowski J, Fitzpatrick JAJ, and Karlseder J (2012). Human telomeres are tethered to the nuclear envelope during post-mitotic nuclear assembly. Cell Rep. 2, 1521-1529. PMID: 23260663.

Hayashi MT, Cesare AJ, Fitzpatrick JAJ, Denchi EL, and Karlseder J (2012). A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat Struct Mol Bio. 19, 387-394. PMID: 22407014.

Kaul Z, Cesare AJ, Huschtscha LI, Neumann AA, and Reddel RR (2012). Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Reports. 13, 52-59. PMID: 22157895.

Basenko E*, Cesare AJ*, Iyer S, Griffith JD, and McEachern MJ (2010). Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination.  Nucleic Acids Res. 38, 182-189 (*equal contribution). PMID: 19858100.

Cesare AJ, Kaul Z, Cohen, SB, Napier CE, Pickett HA, Neumann AA, and Reddel RR (2009). Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions.  Nat Struct Mol Bio. 16, 1244-1251. PMID: 19935685.

Pickett HA, Cesare AJ, Johnston RL, Neumann AA, and Reddel RR (2009). Control of telomere length by a trimming mechanism that involves generation of t-circles. EMBO J. 28, 799-809. PMID: 19214183.

Cesare AJ, Groff-Vindman C, Compton SA, McEachern MJ, and Griffith JD (2008). Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain. Mol Cell Bio.  28, 20-29. PMID: 17967889.

Zhong Z-H, Jiang W-Q, Cesare AJ, Neumann AA, Wadhwa R, and Reddel RR (2007). Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J Bio Chem.  282, 29314-29322. PMID: 17693401.

Compton SA, Choi, J-H, Cesare AJ, Özgür S, and Griffith JD (2007). Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomeres cellsCancer Res. 67, 1513-1519. PMID: 17308089.

Other Key Publications

Martin M, Cho J, Cesare AJ, Griffith JD, and Attardi G (2005). Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis. Cell. 123, 1227-1240. PMID: 16377564.

Cesare AJ and Griffith JD (2004). Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loopsMol Cell Bio. 24, 9948-9957. PMID: 15509797.

Cesare AJ, Quinney N, Willcox S, Subramanian D, and Griffith JD (2003). Telomere looping in P. sativum (common garden pea). Plant J. 36, 271-279. PMID: 14535890.

Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, and Sancar A (2003). Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci USA. 100, 1633-1638. PMID: 12578958.

Key Reviews

Cesare AJ and Karlseder J (2012). A three-state model of telomere control over human proliferative boundaries. Curr Opin Cell Bio. 24, 731-738. PMID: 22947495.

Cesare AJ and Reddel RR (2010). Alternative Lengthening of Telomeres: models, mechanisms and implications. Nature Rev Genet. 11, 319-300. PMID: 20351727.

Cesare AJ and Reddel RR (2008). Telomere uncapping and alternative lengthening of telomeres. Mech Ageing and Dev. 129, 99-108. PMID: 18215414.