Finding cures for children's genetic diseases


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  • Genome Integrity Unit
    Genome Integrity Unit
  • Anaphase
  • HeLa H2B TRF1
    HeLa H2B TRF1

Genome Integrity Unit

The Genome Integrity Unit/Cesare Lab studies fundamental causes of cancer and aging.  We seek to understand how our genome (the set of instructions guiding cellular function) is protected from damage, and how when this protection fails, a disease like cancer may result. Much of our research focuses on telomeres, the protective caps at the ends of our chromosomes. We are studying how telomeres act normally during healthy aging to prevent cancer and how disruption in telomere function can result in changes to the genome that promote tumor formation. 

"Our lab is striving to use our ability to modulate telomere biology to better understand fundamental processes in cellular biology, with the hope this knowledge will one day allow us to treat cancers and promote healthy aging." - Tony Cesare

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