Finding cures for children's genetic diseases


Proteomics Funding Boost

The impact of research into proteomics at Children’s Medical Research Institute is about to be boosted, thanks to a grant from Rebecca L Cooper Medical Research Foundation (RLCMRF) of almost $25,000 to buy a micropipette “Puller” (Laser Puller, Sutter Instrument P-2000). The grant money will also contribute to the purchase of a column oven.
Dr. Mark Graham, Group Leader of Synapse Proteomics, says he is extremely grateful to the Foundation, whose grant for the Micropipette Puller is going to support some great research.
“The Foundation has supported us to put together related equipment that adds up to a “needle-in-a-haystack finding machine”. In our case the haystack is millions of unique molecules that exist inside every cell. The needle is the next breakthrough molecule that will tell us the best way to tackle neurological diseases. The Puller itself is involved in making micro-scale channels to push the molecules through before they are detected by a technology called mass spectrometry. The smaller these channels, the better we can sort through the hay.”
The Synapse Proteomics Group will utilise the puller to discover new targets for potential epilepsy drugs.

The cost of the equipment was also partly funded by The Honda Foundation and Bruce Wall Estate.
“Now we have the Puller we can do our research faster and gain a better depth of knowledge” Dr. Graham said. “This means we understand better how cells work and how things go wrong in disease, which can lead us to how to fix it. All of our team are excited to be getting more valuable data from now on!”