CMRI Researcher Tony Cesare lands cover of Nature magazine!
Along with 3 other contributing authors (Makoto T. Hayashi, Teresa Rivera & Jan Karlseder) Tony's paper shows how cells forming a tumour must overcome two barriers before becoming cancerous.
- The first is senescence
- The second is a proliferative block known as crisis
Cells that escape senescence
usually succumb during crisis
, but it has not been clear what triggers cell death at that stage.
What this paper demonstrates is that cells that bypass senescence
in the absence of p53 have shortened telomeres that undergo fusion, and these fusions trigger mitotic delay. During mitotic arrest telomeres are further deprotected and detected by the DNA damage machinery, which leads to cell death.
These findings might offer a clinical opportunity, as exacerbation of mitotic telomere deprotection sensitizes cancer cells to mitotic drugs — but mitotic arrest has also been associated with genome instability and tumorigenesis in checkpoint-compromised cells.
To view the full paper, please click here
Watch the full 26.06.15
Ch7 News exclusive video
featuring Tony here.
Check out the Ch7 Sunrise Morning News featuring 7 News Health Editor, Dr Andrew Rochford who discusses the findings & what this means for patients & the community.