The ACRF International Centre for the Proteome of Human Cancer
ProCan was established with a $10 million grant from the Australian Cancer Research Foundation (ACRF). ProCan is a world-first initiative developed by Professors Phil Robinson and Roger Reddel and is set to launch in September 2016
“ProCan will not only advance basic research into new and better cancer treatments but soon it will also help doctors rapidly choose the best existing treatment for their patients.”
CEO of ACRF
Over the next 5 years, scientists at CMRI will analyse tens of thousands of examples of all types of cancer from all over the world to develop a library of information to advance scientific discovery and enhance clinical treatment worldwide.
This database will mean doctors can effectively narrow down the best type of currently available treatment to target a cancer patient’s individual diagnosis, without having to waste time trialling medications that won’t effectively treat the disease.
The Centre will act in partnership with cancer researchers, clinicians, tumour banks, and technology experts, such as Professor Ruedi Aebersold
in Zurich whose 2015 Nature paper (read here
), acted as the 'proof of concept' for us to undertake, on a much larger scale, the ProCan project.
New technology called PCT-SWATH mass spectrometry will be used to rapidly and simultaneously measure the precise levels of many thousands of proteins in very small cancer biopsies. Working with leading cancer researchers throughout Australia and around the world, the Centre will analyse about 70,000 samples of all types of cancer, starting with childhood leukaemia.
Advanced computer analysis techniques will then be used to compare the protein data with the information that is already available for each cancer, including clinical records such as pathology test results, genetic analyses, genome sequencing, and any previous responses to cancer treatment. This proteogenomics approach to understanding cancer is crucial to speeding up the search for cures, and towards this end, ProCan signed an MOU with the United States' National Cancer Institute as part of Vice President Jo Biden's Cancer Moonshot Initiative
The information generated by ProCan will be free for anyone to access. This will help scientists all over the world studying cancer. What’s more, the library of information created will be a point of reference that can be used now and in the future to aid rapid diagnosis and treatment planning.
Thanks to one of the largest equipment grants in Australian history, $10 million from the ACRF, Phase One
of the project has begun and is well underway with the infrastructure soon to be completed, ready to officially open in September 2016.
Further funding is still needed to achieve Phase Two
, which will employ advanced computer analysis and bioinformatics techniques to compare the protein data with other information available. Phase two is critical if ProCan is to be used to predict the most effective cancer treatments for each individual.
Proteomics is the next step after genomics, and the newest frontier in medical research. Read more.
If you would like to learn more or to contribute to please contact Children's Medical Research Institute.