Cell Biology Unit Publications

Key Publications

1. Bryan TM, Englezou A, Gupta J, Bacchetti S and Reddel RR. (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J., 14: 4240-4248.
   PMID: 7556065
2. Bryan TM, Goodrich KJ and Cech TR. (2000) Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol. Cell, 6: 493-499.
   PMID: 10983995
3. Oganesian L, Moon IK, Bryan TM and Jarstfer MB. (2006) Extension of G-quadruplex DNA by ciliate telomerase. EMBO J., 25, 1148-59.
   PMID: 16511573
4. Oganesian L, Graham ME, Robinson PJ and Bryan TM. (2007) Telomerase recognizes G-quadruplex and linear DNA as distinct substrates. Biochemistry, 46: 11279-90.
   PMID: 17877374
5. Finger SN and Bryan TM. (2008) Multiple DNA binding sites in Tetrahymena telomerase. Nucleic Acids Res., 36: 1260-1272.
   PMID: 18174223

Review Articles

1. Bryan TM and Baumann P (2011).  G-Quadruplexes: From Guanine Gels to Chemotherapeutics.  Mol. Biotechnol., Epub Mar 17.
    PMID: 21416200
2. Bryan TM and Baumann P (2010).  G-quadruplexes: from guanine gels to chemotherapeutics. Methods Mol Biol., 608: 1-16.
   PMID: 20012412
3. Stern JL and Bryan TM. (2009) Telomerase recruitment to telomeres. Cytogenet. Genome Res., 122: 243-54.
   PMID: 19188693
4. Cao Y, Bryan TM and Reddel RR. (2008) Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci., 99: 1092-1099.
   PMID: 18482052
5. Oganesian L and Bryan TM. (2007) Physiological relevance of telomeric G-quadruplex formation: a potential drug target. Bioessays, 29: 155-165.
   PMID: 17226803

Recent Publications

1. Jurczyluk J, Nouwens AS, Holien JK, Adams TE, Lovrecz GO, Parker MW, Cohen SB, Bryan TM. (2010) Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Res., Epub Nov 3.
   PMID: 21051362
2. Cao Y, Huschtscha LI, Nouwens AS, Pickett HA, Neumann AA, Chang AC-M, Toouli CD, Bryan TM, Reddel RR. (2008) Amplification of hTERT in human mammary epithelial cells with limiting hTR expression levels. Cancer Res., 68: 3115-23.
   PMID: 18451136
3. Finger SN, Bryan TM. (2008) Multiple DNA binding sites in Tetrahymena telomerase. Nucleic Acids Res., 36: 1260-1272.
   PMID: 18174223
4. Oganesian L, Graham ME, Robinson PJ, Bryan TM. (2007) Telomerase recognizes G-quadruplex and linear DNA as distinct substrates. Biochemistry, 46: 11279-90.
   PMID: 17877374
5. Chen Y, Fender J, Legassie JD, Jarstfer MB, Bryan TM, Varani G. (2006) Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J., 25: 3156-66.
   PMID: 16778765
6. Oganesian L, Moon IK, Bryan TM, Jarstfer MB. (2006) Extension of G-quadruplex DNA by ciliate telomerase. EMBO J., 25: 1148-59.
   PMID: 16511573
7. Bryan TM, Goodrich KJ, Cech TR. (2003) Tetrahymena telomerase is active as a monomer. Mol. Biol. Cell, 14: 4794-4804.
   PMID: 13679509
8. Bryan TM, Goodrich KJ, Cech TR. (2000) Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol. Cell, 6: 493-499.
   PMID: 10983995
9. Bryan TM, Goodrich KJ, Cech TR. (2000) A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J. Biol. Chem., 275: 24199-24207.
   PMID: 10807925
10. Bryan TM, Sperger JM, Chapman KB, Cech TR. (1998) Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc. Natl. Acad. Sci. USA, 95: 8479-8484.
    PMID: 9671703

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