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Cell Transformation Unit Publications

Key Publications

  1. Hansen RS and Braithwaite AW. (1996) The growth inhibitory function of p53 is separable from transactivation, apoptosis, and suppression of transformation by E1a and ras. Oncogene, 13: 995-1007.
    PMID: 8806689
  2. Hall AR, Dix BR, O'Carroll SJ and Braithwaite AW. (1998) p53 dependent cell death/apoptosis is required for a productive adenovirus infection. Nature Med., 4: 1068-1072.
    PMID: 9734403
  3. Dix BR, O’Carroll SJ, Myers CJ, Edwards SJ and Braithwaite AW. (2000) Efficient induction of cell death by adenoviruses requires binding of E1b55k and p53.  Cancer Res., 60: 2666-2672.
    PMID: 10825139
  4. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite AW and Poulton R. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301: 386-389.
    PMID: 12869766
  5. Lasham A, Moloney S, Hale T, Homer C, Zhang YF, Murison JG, Braithwaite AW and Watson J. (2003) The Y-box-binding protein, YB1, is a potential negative regulator of the p53 tumour suppressor. J. Biol Chem., 278: 35516-35523.
    PMID: 12835324

Review Articles

  1. Braithwaite AW, Del Sal G and Lu X. (2006) Some p53 binding proteins that can function as arbiters of life and death. Cell Death Differ., 13: 984-93.
    PMID: 16575404
  2. Braithwaite AW, Royds JA and Jackson P. (2005) The p53 story: layers of complexity. Carcinogenesis, 26: 1161-1169.
    PMID:15817608
  3. Russell IA, Royds JA, Braithwaite AW. (2004) Exploitation of cell cycle and cell death controls by adenoviruses: the road to a productive infection. Prog. Mol. Subcell. Biol., 36: 207-43.
    PMID: 15171614
  4. Braithwaite AW, Russell IA. (2001) Induction of cell death by adenoviruses. Apoptosis, 6: 359-70.
    PMID: 11483860
  5. Dix BR, Edwards SJ, Braithwaite AW. (2001) Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway? J Virol., 75: 5443-7.
    PMID: 11356950   

Recent Publications

  1. Woolley AG, Algie M, Samuel W, Harfoot R, Wiles A, Hung NA, Tan PH, Hains P, Valova VA, Huschtscha L, Royds JA, Perez D, Yoon HS, Cohen SB, Robinson PJ, Bay BH, Lasham A, Braithwaite AW (2011). Prognostic Association of YB-1 Expression in Breast Cancers: A Matter of Antibody. PLoS One. 2011;6(6):e20603.
    PMID: 21695211
  2. Li CG, Nyman JE, Braithwaite AW and Eccles MR (2011).  PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene, Epub May 23.
    PMID: 21602887
  3. Heinlein C and Speidel D (2011). High-resolution cell cycle and DNA ploidy analysis in tissue samples.  Curr. Protoc. Cytom. Chapter 7: Unit 7.39.
    PMID: 21455969
  4. Slatter TL, Hung N, Campbell H, Rubio C, Mehta R, Renshaw P, Williams G, Wilson M, Engelmann A, Jeffs A, Royds JA, Baird MA and Braithwaite AW (2011).  Hyperproliferation, cancer, and inflammation in mice expressing a {Delta}133p53-like isoform.  Blood, 117: 5166-77.
    PMID: 21411755
  5. Heinlein C, Deppert W, Braithwaite AW, Speidel D.  (2010) A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry.  Cell Cycle, 9: 3584-90.
    PMID: 20928939
  6. Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop Nee Fabbro M.  (2010) The Dynamin Inhibitors MiTMAB and OcTMAB Induce Cytokinesis Failure and Inhibit Cell Proliferation in Human Cancer Cells.  Mol. Cancer Ther., 9: 1995-2006.
    PMID: 20571068
  7. Cohen SB, Ma W, Valova VA, Algie M, Harfoot R, Woolley AG, Robinson PJ, Braithwaite AW. (2009) Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing.  Oncogene, 29: 403-10.
    PMID: 19838214
  8. Slatter TL, Ganesan P, Holzhauer C, Mehta R, Rubio C, Williams G, Wilson M, Royds JA, Baird MA, Braithwaite AW. (2009) p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death Differ., 17: 540-50.
    PMID: 19779492
  9. Huschtscha LI, Moore JD, Noble JR, Campbell HG, Royds JA, Braithwaite AW, Reddel RR. (2009) Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. J. Cell Sci., 122: 2989-95.
    PMID: 19638413
  10. Hibma MH, Real NC, Wiles A, Dobson-Le D, Dix BR, Wynford-Thomas D, Braithwaite AW, Royds JA. (2009) Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Res., 145: 112-20.
    PMID: 19576936  

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