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Cell Biology Unit Publications

Key Publications

  1. Bryan TM, Englezou A, Gupta J, Bacchetti S and Reddel RR. (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J., 14: 4240-4248.
    PMID: 7556065
  2. Bryan TM, Goodrich KJ and Cech TR. (2000) Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol. Cell, 6: 493-499.
    PMID: 10983995
  3. Oganesian L, Moon IK, Bryan TM and Jarstfer MB. (2006) Extension of G-quadruplex DNA by ciliate telomerase. EMBO J., 25, 1148-59.
    PMID: 16511573
  4. Oganesian L, Graham ME, Robinson PJ and Bryan TM. (2007) Telomerase recognizes G-quadruplex and linear DNA as distinct substrates. Biochemistry, 46: 11279-90.
    PMID: 17877374
  5. Finger SN and Bryan TM. (2008) Multiple DNA binding sites in Tetrahymena telomerase. Nucleic Acids Res., 36: 1260-1272.
    PMID: 18174223

Review Articles

  1. Stern JL and Bryan TM. (2009) Telomerase recruitment to telomeres. Cytogenet. Genome Res., 122: 243-54.
    PMID: 19188693
  2. Cao Y, Bryan TM and Reddel RR. (2008) Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci., 99: 1092-1099.
    PMID: 18482052
  3. Oganesian L and Bryan TM. (2007) Physiological relevance of telomeric G-quadruplex formation: a potential drug target. Bioessays, 29: 155-165.
    PMID: 17226803
  4. Bryan TM and Jarstfer MB. (2007) Interrogation of G-quadruplex-protein interactions. Methods, 43: 332-339.
    PMID: 17967703
  5. Reddel RR, Bryan TM, Colgin LM, Perrem KT and Yeager TR. (2001) Alternative lengthening of telomeres in human cells. Radiat. Res., 155: 194-200.
    PMID: 11121234

Recent Publications

  1. Bryan TM, Baumann P. (2010) G-quadruplexes: from guanine gels to chemotherapeutics. Methods Mol Biol., 608: 1-16.
    PMID: 20012412
  2. Cao Y, Huschtscha LI, Nouwens AS, Pickett HA, Neumann AA, Chang AC-M, Toouli CD, Bryan TM, Reddel RR. (2008) Amplification of hTERT in human mammary epithelial cells with limiting hTR expression levels. Cancer Res., 68: 3115-23.
    PMID: 18451136
  3. Finger SN, Bryan TM. (2008) Multiple DNA binding sites in Tetrahymena telomerase. Nucleic Acids Res., 36: 1260-1272.
    PMID: 18174223
  4. Oganesian L, Graham ME, Robinson PJ, Bryan TM. (2007) Telomerase recognizes G-quadruplex and linear DNA as distinct substrates. Biochemistry, 46: 11279-90.
    PMID: 17877374
  5. Chen Y, Fender J, Legassie JD, Jarstfer MB, Bryan TM, Varani G. (2006) Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J., 25: 3156-66.
    PMID: 16778765
  6. Oganesian L, Moon IK, Bryan TM, Jarstfer MB. (2006) Extension of G-quadruplex DNA by ciliate telomerase. EMBO J., 25: 1148-59.
    PMID: 16511573
  7. Bryan TM, Goodrich KJ, Cech TR. (2003) Tetrahymena telomerase is active as a monomer. Mol. Biol. Cell, 14: 4794-4804.
    PMID: 13679509
  8. Bryan TM, Goodrich KJ, Cech TR. (2000) Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol. Cell, 6: 493-499.
    PMID: 10983995
  9. Bryan TM, Goodrich KJ, Cech TR. (2000) A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J. Biol. Chem., 275: 24199-24207.
    PMID: 10807925
  10. Bryan TM, Sperger JM, Chapman KB, Cech TR. (1998) Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc. Natl. Acad. Sci. USA, 95: 8479-8484.
    PMID: 9671703

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