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Cancer Research Unit Publications

 

 

Key Publications

  1. Bryan TM, Englezou A, Gupta J, Bacchetti S and Reddel RR. (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J., 14: 4240-4248.
    PMID: 7556065
  2. Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA and Reddel RR. (1997) Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nature Med., 3: 1271-1274.
    PMID: 9359704
  3. Kilian A, Bowtell DDL, Abud HE, Hime GR, Venter DJ, Keese PK, Duncan EL, Reddel RR and Jefferson RA. (1997) Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum. Mol. Genet., 6: 2011-2019.
    PMID: 9328464
  4. Dunham MA, Neumann AA, Fasching CL and Reddel RR. (2000) Telomere maintenance by recombination in human cells. Nature Genet., 26: 447-450.
    PMID: 11101843
  5. Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ and Reddel RR. (2007) Protein composition of catalytically active human telomerase from immortal cells. Science, 315: 1850-3.
    PMID: 17395830

Review Articles

  1. Henson JD, Reddel RR.  (2010) Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.  FEBS Lett., 584 (17): 3800-11.
    PMID: 20542034
  2. Capes-Davis A, Theodosopoulos G, Atkin I, Drexler HG, Kohara A, Macleod RA, Masters JR, Nakamura Y, Reid YA, Reddel RR, Freshney RI.  (2010) Check your cultures! A list of cross-contaminated or misidentified cell lines.  Int. J Cancer, 127 (1): 1-8.
    PMID: 20143388 
  3. Cesare AJ and Reddel RR.  (2010) Alternative lengthening of telomeres: models, methods and implications.  Nat. Rev. Genet., 11 (5): 319-30.
    PMID: 20351727
  4. Reddel RR. (2010) Senescence: an antiviral defense that is tumor suppressive? Carcinogenesis, 31 (1): 19-26.
    PMID: 19887513
  5. Cao Y, Bryan TM and Reddel RR. (2008) Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci., 99: 1092-99.
    PMID: 18482052

 

Recent Publications

  1. Yoon AR, Gao R, Kaul Z, Choi IK, Ryu J, Noble JR, Kato Y, Saito S, Hirano T, Ishii T, Reddel RR, Yun CO, Kaul SC, Wadhwa R (2011). MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region.
    Nucleic Acids Res. Epub Jun 30.
    PMID:21724611
  2. Jiang WQ, Nguyen A, Cao Y, Chang AC and Reddel RR. HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a. PLoS One, 6: e17036.
    PMID: 21347226
  3. Au AY, Hackl T, Yeager TR, Cohen SB, Pass HI, Harris CC and Reddel RR. (2011) Telomerase activity in pleural malignant mesotheliomas.  Lung Cancer, Epub Jan 28.
    PMID: 21277646
  4. McDonald KL, McDonnell J, Muntoni A, Henson JD, Hegi ME, von Deimling A, Wheeler HR, Cook RJ, Biggs MT, Little NS, Robinson BG, Reddel RR, Royds JA. (2010) Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival. J. Neuropathol. Exp. Neurol., 69: 729-36.
    PMID: 20535033 
  5. Cesare AJ, Kaul Z, Cohen SB, Napier CE, Pickett HA, Neumann AA, Reddel RR. (2009) Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nat. Struct. Mol. Biol., 16: 1244-51.
    PMID: 19935685
  6. Henson JD, Cao Y, Huschtscha LI, Chang AC, Au AY, Pickett HA, Reddel RR. (2009) DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nat. Biotechnol., 27: 1181-5.
    PMID: 19935656
  7. Yuan J, Yang BM, Zhong ZH, Shats I, Milyavsky M, Rotter V, Lock RB, Reddel RR, MacKenzie KL. (2009) Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. Oncogene, 28: 2678-89.
    PMID: 19483728
  8. Huschtscha LI, Moore JD, Noble JR, Campbell HG, Royds JA, Braithwaite AW, Reddel RR. (2009) Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. J Cell Sci., 122: 2989-95.
    PMID: 19638413
  9. Yuan J, Yang BM, Zhong ZH, Shats I, Milyavsky M, Rotter V, Lock RB, Reddel RR, MacKenzie KL. (2009) Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. Oncogene, 28: 2678-89.
    PMID: 19483728
  10. Hinshelwood RA, Melki JR, Huschtscha LI, Paul C, Song JZ, Stirzaker C, Reddel RR, Clark SJ. (2009) Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning. Hum. Mol. Genet., 18: 3098-109.
    PMID: 19477956  

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